Correlating the interaction of colloidal nano- and micorparticles with cells to their physicochemical properties

Presenter:Wolfgang J. Parak

Philipps Universität Marburg, Marburg, Germany & CICBiomagune, San Sebastian, Spain

Time:Jan.20th 2015(Tuesday)9:00am

Venue:Research Institute of Micro/Nano Science and Technology 2-103

Colloidal nano- and microparticles are incorporated by cells. Uptake and also toxic effect can be correlated with physicochemical parameters of the particles. Methods and examples will be discussed.

References:

R. Hartmann, M. Weidenbach, M. Neubauer, A. Fery, W. J. Parak, „Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles”, AngewandteChemie, in press, DOI: 10.1002/anie.201409693.

D. Hühn, K. Kantner, C. Geidel, S. Brandholt, I. De Cock, S. J. Soenen, P. Rivera Gil, J. M. Montenegro Martos, K. Braeckmans, K. Müllen, G. U. Nienhaus, M. Klapper, W. J. Parak, "Polymer-coated nanoparticles interacting with proteins and cells: Focusing on the sign of the net charge", ACS Nano7, 3253–3263 (2013).

M. Nazarenus, Q. Zhang, M. G. Soliman, P. del Pino, B. Pelaz, S. Carregal-Romero, J. Rejman, B. Rothen-Rutishauser, M. J. D. Clift, R. Zellner, G. U. Nienhaus, J. B. Delehanty, I. L. Medintz, W. J. Parak, “Interaction of Colloidal Nanoparticles with Mammalian Cells: What Have We Learned Thus Far?”, Beilstein Journal of Nanotechnology5, 1477–1490 (2014).

W. Kreyling, A. M. Abdelmonem, A. Wenk, D. Jimenez de Aberasturi, A. Zulqurnain, J.-M. Montenegro, S. Hirn, I. Ruiz de Larramendi, T. Rojo, N. Haberl, G. Khadem-Saba, W. J. Parak, "In vivo integrity of colloidal nanoparticles", Nature Nanotechnology, in revision.

 

Bio:

1989-1997  General Physics studies at the TechnischeUniversitätMünchen, Germany

1995-1997   Diploma thesis ("Diplomarbeit") at the Technische Universität München, Germany

1997-1999 Graduate student at the Ludwig Maximilians Universität München, Germany,

2000-2002 Postdoc at the Department of Chemistry at the University of California at Berkeley, California, USA,

2003-2006 Leader of a Junior Research Group (Emmy-Noether fellowship of the German Research Foundation (DFG),

2005      Temporary position as Associate Professor for Physical Chemistry at the Department of Chemistry and Pharmacy at the Ludwig Maximilians Universität München,  Germany for the Summer Semester

since 2007   Full Professor (chair) for Experimental Physics at the Philipps-University of Marburg, Germany

since 2013   in addition head of the Biofunctional Nanomaterials Unit at CICbiomaGUNE, San Sebastian, Spain

          2009 "Nanoscience" - award 2008 from the Association of Nanotechnology-Centres Germany (AGenNT)

          since 2010 Associate Editor for ACS Nano from the American Chemical Society

          2011 ranked #59 in Top Materials Scientists of the past decade by Essential Science Indicators   (http://science.thomsonreuters.com/products/esi/)

          2012 Awarded Chinese Academy of Sciences Visiting Professorship for Senior International Scientists

          2014 highly cited in the category materials sciences (http://highlycited.com/)

          2014listed in “The World’s Most Influential Scientific Minds: 2014” (http://www.sciencewatch.com)

  present h-index: 55

[ 2015-01-19 ]